3hhc
From Proteopedia
Interferon-lambda is functionally an interferon but structurally related to the IL-10 family
Structural highlights
Function[IL28B_HUMAN] Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedInterferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambdaR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion, our data show that, although IFN-lambda is functionally an interferon, it is clearly structurally related to members of the IL-10 family. In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively. Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.,Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R J Biol Chem. 2009 Jul 31;284(31):20869-75. Epub 2009 May 20. PMID:19457860[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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Categories: Homo sapiens | Gad, H H | Hamming, O J | R., Hartmann | Antiviral | Antiviral defense | Cytokine | Il-22 | Interferon | Secreted
