1d5v

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SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.

Disease

Known diseases associated with this structure: Lymphedema and ptosis OMIM:[602402], Lymphedema, hereditary II OMIM:[602402], Lymphedema-distichiasis syndrome OMIM:[602402], Lymphedema-distichiasis syndrome with renal disease and diabetes mellitus OMIM:[602402], Yellow nail syndrome OMIM:[602402]

About this Structure

1D5V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11., van Dongen MJ, Cederberg A, Carlsson P, Enerback S, Wikstrom M, J Mol Biol. 2000 Feb 18;296(2):351-9. PMID:10669593

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