1dgi

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spinqualitylabelsall models PDB ID 1dgi Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 22.0Å
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Cryo-EM structure of human poliovirus(serotype 1)complexed with three domain CD155

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The structure of the extracellular, three-domain poliovirus receptor (CD155) complexed with poliovirus (serotype 1) has been determined to 22-A resolution by means of cryo-electron microscopy and three-dimensional image-reconstruction techniques. Density corresponding to the receptor was isolated in a difference electron density map and fitted with known structures, homologous to those of the three individual CD155 Ig-like domains. The fit was confirmed by the location of carbohydrate moieties in the CD155 glycoprotein, the conserved properties of elbow angles in the structures of cell surface molecules with Ig-like folds, and the concordance with prior results of CD155 and poliovirus mutagenesis. CD155 binds in the poliovirus "canyon" and has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. However, the orientation of the long, slender CD155 molecule relative to the poliovirus surface is quite different from the orientation of intercellular adhesion molecule-1 on rhinoviruses. In addition, the residues that provide specificity of recognition differ for the two receptors. The principal feature of receptor binding common to these two picornaviruses is the site in the canyon at which binding occurs. This site may be a trigger for initiation of the subsequent uncoating step required for viral infection.

Disease

Known diseases associated with this structure: Polio, susceptibility to OMIM:[173850]

About this Structure

1DGI is a Protein complex structure of sequences from Homo sapiens and Human poliovirus 1. The following page contains interesting information on the relation of 1DGI with [Poliovirus and Rhinovirus]. Full crystallographic information is available from OCA.

Reference

Interaction of the poliovirus receptor with poliovirus., He Y, Bowman VD, Mueller S, Bator CM, Bella J, Peng X, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG, Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):79-84. PMID:10618374

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