2d93

Structural highlights

Function

[RPGF6_HUMAN] Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim Biophys Acta. 2003 Feb 17;1593(2-3):141-9. PMID:12581858
2. ↑ Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. J Biol Chem. 2001 Nov 9;276(45):42219-25. Epub 2001 Aug 27. PMID:11524421 doi:http://dx.doi.org/10.1074/jbc.M105760200