5e8n

Structural highlights

Function

[HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. [CERS5_MOUSE] Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1.^{[1] [2]} [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

References

1. ↑ Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem. 2003 Oct 31;278(44):43452-9. Epub 2003 Aug 11. PMID:12912983 doi:http://dx.doi.org/10.1074/jbc.M307104200
2. ↑ Lahiri S, Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem. 2005 Oct 7;280(40):33735-8. Epub 2005 Aug 12. PMID:16100120 doi:http://dx.doi.org/10.1074/jbc.M506485200