Function
Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity.[1] Some details on EGF exon in EGF1; on Gla domain in Gla domain.
Relevance
EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination.
Structural highlights
All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds.
