Sandbox Reserved 427

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Vitamin D binding protein (1j7e) 2 Introduction 3 Overall Structure 4 Binding Interactions 5 Additional Features 5.1 Actin Binding Interactions 5.2 Role in Disease 5.3 Other Notable Ligands 6 Quiz Question 1 7 See Also 8 Credits 9 References

Vitamin D binding protein (1j7e)

by Alex Debreceni, Robert Green, Uday Prakhya, Nicholas Rivelli, Elizabeth Swanson

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

spinqualitylabelsall models 1j7e, Vitamin D Binding Protein Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This is a sample scene created with SAT to by Group, and another to make of the protein.

Overall Structure

spinqualitylabelsall models 1j7e, Vitamin D Binding Protein Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Alpha Helices</

Binding Interactions

spinqualitylabelsall models pdbcode, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Additional Features

Actin Binding Interactions

Role in Disease

Other Notable Ligands

spinqualitylabelsall models 1j7e, The multiple binding sites of DBP allow it to carry ligands other than oleic acid. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Quiz Question 1

spinqualitylabelsall models pdbcode, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

See Also

• 1kxp
• 1kw2
• 1j7e
• 1j78
• 1ma9
• 1lot

Credits

Introduction - Uday Prakhya

Overall Structure - Elizabeth Swanson

Drug Binding Site - Alex Debreceni

Additional Features - Nick Rivelli

Quiz Question 1 - Robert Green

References

[1] Gomme PT, Bertolini J. 2004. Therapeutic potential of vitamin D-binding protein. Trends Biotechnol. 22:340–345.

[2] Haddad JG. 1995. Plasma vitamin D-binding protein (Gc-globulin): Multiple tasks. J. Steroid Biochem. Mol. Biol. 53:579–582.

[3] Speeckaert M, Huang G, Delanghe JR, Taes YEC. 2006. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin. Chim. Acta 372:33–42.

[4] Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C. 2002. A structural basis for the unique binding features of the human vitamin D-binding protein. Nat. Struct. Biol. 9:131–6.

[5] White P, Cooke N. 2000. The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol. Metab. 11:320–327.