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Domain

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A protein domain is a sequence of amino acids that can fold, independently of the remainder of the full-length sequence, into a compact stable structure. Water-soluble domains typically have hydrophobic cores. Some small full-length proteins consist of a single domain, but most proteins have two or more domains. A domain is typically 100-250 amino acids in length[1], but can sometimes be shorter or longer.

Examples:

  • Each of the 4 chains that form hemoglobin (a tetramer) folds into a single domain. See 2hhd.

For more information see Protein Domain in Wikipedia.

See also [1] and this summary of it.

References

  1. ↑ 1.0 1.1 Evolution of the protein repertoire. Cyrus Chothia, Julian Gough, Christine Vogel, Sarah A. Teichmann (2003). Science 300:1701-3. PMID:12805536

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Jaime Prilusky

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