Phosphoglycerate dehydrogenase

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Human phosphoglycerate dehydrogenase dimer complex with malate and cofactor NAD 2g76

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Phosphoglycerate dehydrogenase (PGDH) catalyzes the conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate. This is the first step of serine biosynthesis. NAD is used as cofactor. In some cancer cells there is an elevation in PGDH level.

3D structures of phosphoglycerate dehydrogenase

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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