Trypsin is a Serine protease. It catalyzes peptide bond hydrolysis in two sequential steps. In the first (acylation) reaction, the nucleophilic serine attacks the substrate scissile bond, forming first a tetrahedral intermediate and then a covalent acyl-enzyme with release of the C-terminal fragment. In the second (deacylation) reaction, a water molecule attacks the acyl-enzyme, leading to a second tetrahedral intermediate followed by release of the N-terminal fragment. Sandbox Wabash07. Click above on edit this page to modify. Be careful with the < and > signs.
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Function
Disease
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Structural highlights
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