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From Proteopedia

Human metabotropic glutamate receptor 5 transmembrane domain

spinqualitylabelsall models Human metabotropic glutamate receptor 5 transmembrane domain Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image The Human metabotropic glutamate receptor 5 transmembrane domain is a Contents 1 Structure 1.1 Binding Pocket 1.2 Ionic Locks 2 Function and Pathway 3 Disease 3.1 Fragile X 3.2 Parkinsons 4 Relevance 5 Structural highlights Structure Figure Legend Binding Pocket Ionic Locks This is the . Function and Pathway Disease Fragile X Parkinsons Relevance Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

1.Clemmensen, C., Smajilovic, S., Wellendorph, P., and Brauner-Osborne, H. (2013). “The GPCR, class C, group 6, subtype A (GPCR6A) receptor: from cloning to physiological function.” British Journal of Pharmacology. 171: 1129-41. 2. Dore, Andrew S., Okrasa, Krzysztof, Okrasa., Patel,, Jayesh, C., Serrano-Vega, Maria., Bennett, Kirstie., Cooke, Robert M., Errey, James C., Jazayeri, Ali., Khan, Samir., Tehan, Ben., Weir, Malcolm., Wiggin, Giselle R., Marshall, Fiona H. (2014) “Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.” Nature. 511: 557-62. 3.Feng, Zhiwei, Shifan Ma, Guanxing Hu, and Xiang-Qun Xie.(2015). "Allosteric Binding Site and Activation Mechanism of Class C G-Protein Coupled Receptors: Metabotropic Glutamate Receptor Family." The AAPS Journal AAPS J 17.3 (2015): 737-53. 4Niswender, Colleen M., and P. Jeffrey Conn.(2010). "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease." Annu. Rev. Pharmacol. Toxicol. Annual Review of Pharmacology and Toxicology 50.1: 295-322. Web. 5"Novartis Announces Results of Mavoglurant (mGluR5) (AFQ056) Clinical Trials and the Conclusion of the Long-Term Extension Study" (2014). NFXF. Foward, 24 Apr. Web. 6. Wu, Huixian, Wang, Chong, Gregory, Karen J., Han, Gye W., Cho, Hyekyung P., Xia, Yan, Niswender, Colleen M., Katritch, Vsevolod, Meiler, Jens, Cherezov, Vadim, Conn, P.J., Stevens, Raymond C. (2014) “Structure of class C GPCR metabotropic glutamate receptor 1 Bound to an Allosteric Modulator.” Science. 344: 58-64. 7. Woodcook, Elizabeth A., Kistler, Peter M., Ju, Yue-Kun. (2009) “Phosphoinositide signalling and cardiac arrhythmias.” European Society of Cardiology. 82: 286-95. 8."4009."(2014). Structure of the Human Class C GPCR Metabotropic Glutamate Receptor 5 Transmembrane Domain in Complex with the Negative Allosteric Modulator Mavoglurant. RCSB PDB, n.d. Web. 22 Feb. 2016