User:Daniel Schemenauer/Sandbox 1

From Proteopedia

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 metabotropic Glutamate Receptor 5 Homo sapiens 2 Introduction 2.1 Biological Background 2.2 Importance 3 Structure 3.1 Overall Stucture 3.2 Key Interactions 4 Disease 5 Clinical Relevance metabotropic Glutamate Receptor 5 Homo sapiens Introduction Biological Background G-Coupled Protein Receptors (GPCRs) are divided into four major classes; Class A,B,C, and F.[1] Importance [2] Structure Overall Stucture Key Interactions Disease Clinical Relevance Hydrophobic Pocket Surrounding Mavoglurant Image:Mav HB 1.1.png Hydrogen Bonding interactions between protein and Mavoglurant Further Hydrogen Bonding between protein and Mavoglurant

References

1. ↑ Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, Babu MM. Molecular signatures of G-protein-coupled receptors. Nature. 2013 Feb 14;494(7436):185-94. doi: 10.1038/nature11896. PMID:23407534 doi:http://dx.doi.org/10.1038/nature11896
2. ↑ Bracey MH, Hanson MA, Masuda KR, Stevens RC, Cravatt BF. Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science. 2002 Nov 29;298(5599):1793-6. PMID:12459591 doi:10.1126/science.1076535

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