Insulin-like growth factor binding protein

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Insulin-like growth factor binding protein (IGFBP) are 7 homologous proteins which bind insulin-like growth factor I (IGF I)[1]. The N-terminal of IGFBP is the domain which binds IGF I. Disease IGFBP-3 and IGFBP-6 show inhibition of angiogenesis and promotion of cancer cell migration[2],[3]. IGFBP-4 overexpression inhibits the growth of colon and prostate cancer cells[4]. IGFBP-1 is closely related to risk factors for diabetes and cardiovascular disease[5]. Relevance Structural highlights

3D structures of insulin-like growth factor binding protein

Updated on 29-March-2016

References

1. ↑ Hwa V, Oh Y, Rosenfeld RG. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev. 1999 Dec;20(6):761-87. PMID:10605625 doi:http://dx.doi.org/10.1210/edrv.20.6.0382
2. ↑ Bach LA, Fu P, Yang Z. Insulin-like growth factor-binding protein-6 and cancer. Clin Sci (Lond). 2013 Feb;124(4):215-29. doi: 10.1042/CS20120343. PMID:23126425 doi:http://dx.doi.org/10.1042/CS20120343
3. ↑ PMID:9815544</ref.
   
   • IGFBP-3 level is decreased in patients with inflammatory bowel disease<ref>PMID:15844718</li>
   <li id="cite_note-3">[[#cite_ref-3|↑]] Durai R, Davies M, Yang W, Yang SY, Seifalian A, Goldspink G, Winslet M. Biology of insulin-like growth factor binding protein-4 and its role in cancer (review). Int J Oncol. 2006 Jun;28(6):1317-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16685432 16685432] </li> <li id="cite_note-4">[[#cite_ref-4|↑]] Heald AH, Cruickshank JK, Riste LK, Cade JE, Anderson S, Greenhalgh A, Sampayo J, Taylor W, Fraser W, White A, Gibson JM. Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations. Diabetologia. 2001 Mar;44(3):333-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11317665 11317665] doi:[http://dx.doi.org/10.1007/s001250051623 http://dx.doi.org/10.1007/s001250051623]</li></ol></ref>