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Neurotensin
is a 13-amino acid peptide originally isolated from bovine hypothalamus. It fulfills the role of both a neurotransmitter and a neuromodulator in the nervous system and a hormone in the periphery. NTS is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It is also a paracrine and endocrine modulator in the periphery of the digestive tract and cardiovascular system. Finally, NTS serves as a growth factor for many normal and cancerous cell types.(Vincent)
Only the C-terminal tail of NTS, amino acids 8-13, were resolved in the crystal structure.
Binding Site
Binding of NTS to the binding site is enriched by between the positive NTS arginine side chains and the electronegative pocket. In addition, the C-terminus forms a with R328. Only three out of eight hydrogen bonds are made between the side chains of NTS and the receptor. Most of the interactions are van der Waals interactions. The binding pocket is partially capped by a hairpin loop at the proximal end of the receptor protein's N-terminus. (White)
Function
Disease
Relevance
Structural highlights
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