Leukotriene A4 Hydrolase

From Proteopedia

Revision as of 10:42, 11 April 2016 by Michal Harel (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

Human leukotriene A4 Hydrolase complex with bestatin, acetate, imidazole, Yb+3 (green) and Zn+2 (grey) ions (PDB entry 1hs6)

Drag the structure with the mouse to rotate

1 Function
2 Relevance
3 Disease
4 3D Structures of Leukotriene A4 Hydrolase

Function

Leukotriene A4 Hydrolase (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism^[1] .

Relevance

LTA4H inhibitors have potential in targeting chronic, autoimmune-driven inflammation^[2] .

Disease

Mutations in LTA4H are linked to susceptibility to asthma and to cardiovascular disease.

3D Structures of Leukotriene A4 Hydrolase

Updated on 11-April-2016

== References ==

↑ Paige M, Wang K, Burdick M, Park S, Cha J, Jeffery E, Sherman N, Shim YM. Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. J Immunol. 2014 Jun 1;192(11):5059-68. doi: 10.4049/jimmunol.1400452. Epub 2014, Apr 25. PMID:24771855 doi:http://dx.doi.org/10.4049/jimmunol.1400452
↑ Fourie AM. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr Opin Investig Drugs. 2009 Nov;10(11):1173-82. PMID:19876785