Function
The M2 protein (M2) is a proton selective ion channel of the influenza virus[1]. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:
M2 Proton Channel
Molecular Playground/Influenza A M2 transmembrane domain
M2 Proton Channel Inhibitor Pharmacokinetics.
3D structures of M2 protein
Updated on 14-April-2016
3lbw – IavM2 TM (mutant) – Influenza A virus
3bkd - IavM2 TM
3c9j - IavM2 TM + amantadine
2rlf - IavM2 TM +rimantadine - NMR
2kqt, 1mp6, 1nyj, 2h95 - IavM2 TM – NMR
2kih, 2kwx, 2l0j - IavM2 TM (mutant) – NMR
2ljb, 2ljc - IavM2 TM (mutant)/IbvM2 TM – NMR
2kix - IbvM2 TM (mutant) – Influenza B virus – NMR
2kj1 – IbvM2 cytoplasmic domain - NMR
4c3b, 4c3d – hrsvM2 – Human respiratory syncytial virus
4c3e – hrsvM2 (mutant)
2l9j – hrsvM2 core domain (mutant) - NMR
References
- ↑ Betakova T. M2 protein-a proton channel of influenza A virus. Curr Pharm Des. 2007;13(31):3231-5. PMID:18045172
