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Old Stuff:

Fig. 1: A135P Mutation and effect on stalk stability ^[1].

Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.^[1]

Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled^[1].

Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay

Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.

Fig. 7: Active site buried deep in 7TMD of glucagon receptor.

Fig. 9: Location of anchoring pocket within central cavity.^[1]

Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.