NF-kB

NF-kB or Nuclear Factor NF-kappa is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: NF-kB1 (synthesized as p105 and processed to p50), NF-kB2 (synthesized as p100 and processed to p52), RelA (or p65), RelB and cRel. I-κ-B-α is an inhibitor of NF-kB.