Neuropilin

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Contents

Function

Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins[1]. There are 2 classes of NRP – NRP-1 and NRP-2.

  • NRP-1 has high affinity for semaphorin-3A.
  • NRP-2 has high affinity for semaphorin-3F.

Relevance

NRP are highly expressed in human neoplasms[2].

Structural highlights

NPR structure contains the extracellular domains A1, A2 which bind semaphorin; B1, B2 which bind VEGF and C which is the dimerization region.

3D Structures of Neuropilin

Updated on 10-May-2016

References

  1. ↑ Romeo PH, Lemarchandel V, Tordjman R. Neuropilin-1 in the immune system. Adv Exp Med Biol. 2002;515:49-54. PMID:12613542
  2. ↑ Pellet-Many C, Frankel P, Jia H, Zachary I. Neuropilins: structure, function and role in disease. Biochem J. 2008 Apr 15;411(2):211-26. doi: 10.1042/BJ20071639. PMID:18363553 doi:http://dx.doi.org/10.1042/BJ20071639

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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