1ij9
From Proteopedia
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Highly Hydrated Human VCAM-1 Fragment
Contents |
Overview
An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
Disease
Known diseases associated with this structure: CRASH syndrome OMIM:[308840], Corpus callosum, partial agenesis of OMIM:[308840], Hydrocephalus due to aqueductal stenosis OMIM:[308840], Hydrocephalus with Hirschsprung disease and cleft palate OMIM:[308840], Hydrocephalus with congenital idiopathic intestinal pseudoobstruction OMIM:[308840], MASA syndrome OMIM:[308840]
About this Structure
1IJ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement., Taylor P, Bilsland M, Walkinshaw MD, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1579-83. Epub 2001, Oct 25. PMID:11679722
Page seeded by OCA on Thu Mar 20 11:51:03 2008
