Formate dehydrogenase

Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe₄S₄ center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe₄S₄^[1].

3D structure of formate dehydrogenase

Updated on 07-June-2016

References

1. ↑ Ferry JG. Formate dehydrogenase. FEMS Microbiol Rev. 1990 Dec;7(3-4):377-82. PMID:2094290