Outer surface protein

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Outer surface proteins (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. OspA contributes to the colonization of the gut by the bacteria. OspC is a major antigen on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see:
OspA -

OspB -

OspC -

OxpA, OspB and OspC -

3D structures of Outer surface proteins (Updated on 13-June-2016)

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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