Function
Pantothenate synthetase (PS) catalyzes the ATP-dependent condensation of pantoate and β-alanine to form pantothenate.
Relevance
Pantothenate (vitamin B5) biosynthesis is essential for the virulence of Mycobacterium tuberculosis thus its blockage can be used as a potential drug target.
Structural highlights
PS active site is located at the C-terminal of the central parallel β sheet. In this structure the pantoate substrate electron density is well defined in one subunit while the nucleotide electron density is well defined in the other[1].
