Penicillin acylase

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Function

Penicillin acylase (PAH) catalyzes the conversion of penicillin to 6-amino-penicillanate and phenylacetate (PA). PAH contains 2 non-identical subunits. The larger β subunit contains a phenylmethylsulfonyl residue which is required for enzymatic activity. PAH participates in penicillin and cephalosporin biosynthesis.

Relevance

PAH is used commercially for production of semi-synthetic penicillins.

3D structures of penicillin acylase

Updated on 15-June-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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