Function
Peptidyl-prolyl cis-trans isomerase (PPIase) interconverts cis and trans isomers of proline. PPIase functions as a protein folding chaperone.
- PPIase Pin1 isomerizes phospho-serine/threonine proline motifs. The deregulation of Pin1 may be involved in cancer and Alzheimer Disease. Pin1 consists of 2 domains: the WW domain recognizes the pSer/pThr Pro motif and the PPIase domain contains the catalytic site.
- PPIase Mip (macrophage infectivity potentiator) is required for optimal infection of macrophages by some parasites.
- PPIase SlyD acts as a chaperone and speeds up protein folding.
For various types of PPIase see:
• Cyclophilin
• FK506 binding protein for SlyD
• The Escherichia coli sensitive to lysis D (SlyD) protein
• Multifaceted SlyD from Helicobacter pylori: implication in NiFe hydrogenase maturation
Disease
Relevance
Structural highlights
