Phosphoglucose isomerase

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Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of phosphoglucose isomerase 5 References

Function

Phosphoglucose isomerase (PGI) catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate^[1]. PGI is part of the glycolysis cycle. For more details see Phosphoglucoisomerase.

Disease

Increased expression of PGI enhances colorectal cancer metastasis^[2].

Structural highlights

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3D Structures of phosphoglucose isomerase

Updated on 27-June-2016

References

1. ↑ Bahaji A, Sanchez-Lopez AM, De Diego N, Munoz FJ, Baroja-Fernandez E, Li J, Ricarte-Bermejo A, Baslam M, Aranjuelo I, Almagro G, Humplik JF, Novak O, Spichal L, Dolezal K, Pozueta-Romero J. Plastidic phosphoglucose isomerase is an important determinant of starch accumulation in mesophyll cells, growth, photosynthetic capacity, and biosynthesis of plastidic cytokinins in Arabidopsis. PLoS One. 2015 Mar 26;10(3):e0119641. doi: 10.1371/journal.pone.0119641., eCollection 2015. PMID:25811607 doi:http://dx.doi.org/10.1371/journal.pone.0119641
2. ↑ Tsutsumi S, Fukasawa T, Yamauchi H, Kato T, Kigure W, Morita H, Asao T, Kuwano H. Phosphoglucose isomerase enhances colorectal cancer metastasis. Int J Oncol. 2009 Nov;35(5):1117-21. PMID:19787266