Phosphoserine aminotransferase

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Template:STRUCTURE 1bjo

Function

Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT.

Relevance

PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.

3D structures of phosphoserine aminotransferase

Updated on 30-June-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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