Function
Phosphoserine aminotransferase (PSAT) catalyzes the reversible conversion of phosphoserine and oxoglutarate to produce glutamate and 3-phosphonooxypyruvate. PSAT is part of the phosphoserine biosynthesis[1]. Pyridoxal phosphate (vitamin B6, PLP) is a cofactor of PAT.
Relevance
PSAT is over-expressed in colon tumors and its inhibition is being tested as drug treatment.
Structural highlights
PSAT overall structure shows a small domain and a large one. The active site contains the PLP co-factor bound to lysine side chain[2].
