Phosphoserine phosphatase

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spinqualitylabelsall models Phosphoserine phosphatase dimer complex with phosphoserine 1l8o Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 Function 2 Disease 3 Structural highlights 4 3D structures of phosphoserine phosphatase 5 References

Function

Phosphoserine phosphatase (PSP) catalyzes the dephosphorylation of phosphoserine to produce serine and phosphate. This is the last reaction in serine biosynthesis. PSP is part of the glycine, serine and threonine metabolism^[1]. Mg+2 ion is a cofactor of PSP.

Disease

Mutations of PSP were found in patients with Williams syndrome^[2].

Structural highlights

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3D structures of phosphoserine phosphatase

Updated on 03-July-2016

References

1. ↑ NEUHAUS FC, BYRNE WL. Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase. J Biol Chem. 1959 Jan;234(1):113-21. PMID:13610904
2. ↑ Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. PMID:9222972