Porphobilinogen synthase

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Porphobilinogen synthase (PBS) catalyzes the formation of porphobilinogen (PBG) from 2 molecules of aminolevulinic acid (ALA). PBS participates in porphyrin biosynthesis. Levulinic acid (LA) is an inhibitor of PBS. Porphyrin is the precursor of hemes, chlorophyll and vitamin B12. PBS deficiency can be caused by lead and other heavy metal poisoning.

3D structures of porphobilinogen synthase

Updated on 04-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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