1jsu

From Proteopedia

Revision as of 10:08, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1jsu.gif


PDB ID 1jsu

Drag the structure with the mouse to rotate
, resolution 2.3Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



P27(KIP1)/CYCLIN A/CDK2 COMPLEX


Contents

Overview

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

Disease

Known diseases associated with this structure: Multiple endocrine neoplasia, type IV OMIM:[600778]

About this Structure

1JSU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460

Page seeded by OCA on Thu Mar 20 12:07:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jsu"
Personal tools