1k78
From Proteopedia
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| , resolution 2.25Å | |||||||
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| Gene: | PAX5 (Homo sapiens), ETS-1 (Mus musculus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Pax5(1-149)+Ets-1(331-440)+DNA
Contents |
Overview
Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.
Disease
Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]
About this Structure
1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502
Page seeded by OCA on Thu Mar 20 12:13:29 2008
