Pyruvate dehydrogenase kinase

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Template:STRUCTURE 1jm6

Function

Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites[1].

Relevance

Inhibition of PDK decreases the damage caused by heart ischemia and are used in diabetes and cancer patients[2][3].

3D structures of pyruvate dehydrogenase kinase

Updated on 02-August-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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