4b1a

Publication Abstract from PubMed

The complex fac-[Mo(CO)(3)(histidinate)]Na has been reported to be an effective CO-Releasing Molecule in vivo, eliciting therapeutic effects in several animal models of disease. The CO releasing profile of this complex in different settings both in vitro and in vivo reveals that the compound can readily liberate all of its three CO equivalents under biological conditions. The compound has low toxicity and cytotoxicity and is not hemolytic. CO release is accompanied by a decrease in arterial blood pressure following administration in vivo. We studied its behavior in solution and upon the interaction with proteins. Reactive oxygen species (ROS) generation upon exposure to air and polyoxomolybdate formation in soaks with lysozyme crystals were observed as processes ensuing from the decomposition of the complex and the release of CO.

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics.,Seixas JD, Mukhopadhyay A, Santos-Silva T, Otterbein LE, Gallo DJ, Rodrigues SS, Guerreiro BH, Goncalves AM, Penacho N, Marques AR, Coelho AC, Reis PM, Romao MJ, Romao CC Dalton Trans. 2012 Dec 7. PMID:23223860^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.