1kn2

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spinqualitylabelsall models PDB ID 1kn2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 1.90Å
Ligands:	and
Coordinates:	save as pdb, mmCIF, xml

CATALYTIC ANTIBODY D2.3 COMPLEX

Overview

The crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior.

About this Structure

1KN2 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:11878955

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