Structural highlights
3u0x is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 1lz7, 1lzj, 2rit, 2rix, 2rj8 |
| Gene: | ABO (HUMAN) |
| Activity: | Fucosylgalactoside 3-alpha-galactosyltransferase, with EC number 2.4.1.37 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
