| Structural highlights
Function
[LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Publication Abstract from PubMed
In this paper we present the synthesis and SAR as well as selectivity, pharmacokinetic and infection model data for representative analogs of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections.,Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels J, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mulllins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello D, Warmus J, Wishka DG J Med Chem. 2011 Dec 18. PMID:22175825[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels J, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mulllins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello D, Warmus J, Wishka DG. Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections. J Med Chem. 2011 Dec 18. PMID:22175825 doi:10.1021/jm2014748
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