Structural highlights
3go3 is a 4 chain structure with sequence from Streptomyces echinatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| NonStd Res: | , , , |
| Related: | 185d, 193d, 1pfe, 1vs2, 1xvk, 1xvn, 1xvr, 2adw, 2da8 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This complex crystallizes in a different space group compared with related complexes and shows a different mode of base pairing next to the bis-intercalation site, suggesting that the energy difference between Hoogsteen and Watson-Crick pairing is rather small. The binding of manganese to N7 of guanine is only possible because of DNA unwinding induced by the echinomycin, which might help to explain the mode of action of the drug.
Interaction of an echinomycin-DNA complex with manganese ions.,Pfoh R, Cuesta-Seijo JA, Sheldrick GM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt, 7):660-4. Epub 2009 Jun 27. PMID:19574634[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pfoh R, Cuesta-Seijo JA, Sheldrick GM. Interaction of an echinomycin-DNA complex with manganese ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt, 7):660-4. Epub 2009 Jun 27. PMID:19574634 doi:10.1107/S1744309109019654
