Structural highlights
Publication Abstract from PubMed
Cyclic constraints have proven to be very effective for preorganizing beta-amino acid residues and thereby stabilizing beta- and alpha/beta-peptide helices, but little is known about possible preorganization effects among gamma residues. Here we assess and compare the impact of cyclic preorganization of beta and gamma residues in the context of a specific alpha/beta/gamma-peptide helix. The results show that beta residue preorganization is critical for helix stability but that gamma residue preorganization is less important.
Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water.,Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH J Am Chem Soc. 2013 May 23. PMID:23701135[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Shin YH, Mortenson DE, Satyshur KA, Forest KT, Gellman SH. Differential Impact of beta and gamma Residue Preorganization on alpha/beta/gamma-Peptide Helix Stability in Water. J Am Chem Soc. 2013 May 23. PMID:23701135 doi:10.1021/ja403319q
