1lof

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spinqualitylabelsall models PDB ID 1lof Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.3Å
Ligands:	, and
Coordinates:	save as pdb, mmCIF, xml

X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION

Overview

The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.

About this Structure

1LOF is a Protein complex structure of sequences from Lathyrus ochrus. Full crystallographic information is available from OCA.

Reference

X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588

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