3pz7

Structural highlights

Function

[DIXC1_HUMAN] Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.^{[1] [2]}

References

1. ↑ Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. J Biol Chem. 2004 Sep 17;279(38):39366-73. Epub 2004 Jul 15. PMID:15262978 doi:http://dx.doi.org/10.1074/jbc.M404598200
2. ↑ Liu YT, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW. Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem. 2011 Mar 11;286(10):8597-608. Epub 2010 Dec 28. PMID:21189423 doi:10.1074/jbc.M110.186742