1m6b
From Proteopedia
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| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the HER3 (ERBB3) Extracellular Domain
Contents |
Overview
We have determined the 2.6 angstrom crystal structure of the entire extracellular region of human HER3 (ErbB3), a member of the epidermal growth factor receptor (EGFR) family. The structure consists of four domains with structural homology to domains found in the type I insulin-like growth factor receptor. The HER3 structure reveals a contact between domains II and IV that constrains the relative orientations of ligand-binding domains and provides a structural basis for understanding both multiple-affinity forms of EGFRs and conformational changes induced in the receptor by ligand binding during signaling. These results also suggest new therapeutic approaches to modulating the behavior of members of the EGFR family.
Disease
Known disease associated with this structure: Lethal congenital contractural syndrome 2 OMIM:[190151]
About this Structure
1M6B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the extracellular region of HER3 reveals an interdomain tether., Cho HS, Leahy DJ, Science. 2002 Aug 23;297(5585):1330-3. Epub 2002 Aug 1. PMID:12154198
Page seeded by OCA on Thu Mar 20 12:39:27 2008
