Structural highlights
4e02 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 3tz0, 3tz2, 3tz4, 3tz5, 4dzy, 4e01 |
| Gene: | Bckdk (Rattus norvegicus) |
| Activity: | [3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number 2.7.11.4 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
