Structural highlights
Function
[A1AG2_HUMAN] Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.[1]
References
- ↑ Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M. Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms. J Biol Chem. 2011 Apr 22;286(16):14427-34. Epub 2011 Feb 24. PMID:21349832 doi:http://dx.doi.org/10.1074/jbc.M110.208926
