3oei

Structural highlights

Function

[Y3357_MYCTU] Antitoxin component of a toxin-antitoxin (TA) module. A probable antitoxin for the putative mRNA interferase RelK. Upon expression in E.coli but not in M.smegmatis this protein neutralizes E.coli YoeB.^{[1] [2] [3] [4]} Binds to and represses its own promoter, in combination with RelK repression is somewhat lessened. Several DNA-protein complexes are formed in vitro depending on the RelJ:RelK ratio.^{[5] [6] [7] [8]}

References

1. ↑ Korch SB, Contreras H, Clark-Curtiss JE. Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. J Bacteriol. 2009 Mar;191(5):1618-30. doi: 10.1128/JB.01318-08. Epub 2008 Dec 29. PMID:19114484 doi:http://dx.doi.org/10.1128/JB.01318-08
2. ↑ Ramage HR, Connolly LE, Cox JS. Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 2009 Dec;5(12):e1000767. doi: 10.1371/journal.pgen.1000767. Epub 2009, Dec 11. PMID:20011113 doi:http://dx.doi.org/10.1371/journal.pgen.1000767
3. ↑ Yang M, Gao C, Wang Y, Zhang H, He ZG. Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PLoS One. 2010 May 17;5(5):e10672. doi: 10.1371/journal.pone.0010672. PMID:20498855 doi:http://dx.doi.org/10.1371/journal.pone.0010672
4. ↑ Kumar P, Issac B, Dodson EJ, Turkenburg JP, Mande SC. Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. J Mol Biol. 2008 Nov 14;383(3):482-93. Epub 2008 Sep 4. PMID:18793646 doi:http://dx.doi.org/S0022-2836(08)01085-1
5. ↑ Korch SB, Contreras H, Clark-Curtiss JE. Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages. J Bacteriol. 2009 Mar;191(5):1618-30. doi: 10.1128/JB.01318-08. Epub 2008 Dec 29. PMID:19114484 doi:http://dx.doi.org/10.1128/JB.01318-08
6. ↑ Ramage HR, Connolly LE, Cox JS. Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 2009 Dec;5(12):e1000767. doi: 10.1371/journal.pgen.1000767. Epub 2009, Dec 11. PMID:20011113 doi:http://dx.doi.org/10.1371/journal.pgen.1000767
7. ↑ Yang M, Gao C, Wang Y, Zhang H, He ZG. Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PLoS One. 2010 May 17;5(5):e10672. doi: 10.1371/journal.pone.0010672. PMID:20498855 doi:http://dx.doi.org/10.1371/journal.pone.0010672
8. ↑ Kumar P, Issac B, Dodson EJ, Turkenburg JP, Mande SC. Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. J Mol Biol. 2008 Nov 14;383(3):482-93. Epub 2008 Sep 4. PMID:18793646 doi:http://dx.doi.org/S0022-2836(08)01085-1