Response regulator

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Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain.

• RR CheY is a chemotaxis response regulator in bacteria^[1].
  
• RR Spo0 is the sporulation response regulator^[2].
  
• RR PleD is required in loss of motility^[3]. For details see PleD activation, PleD allosteric product inhibition, PleD catalysis and Response regulator PLED in complex with C-di-GMP
  
• RR PhoP is important for survival under conditions of macrophage-induced stress^[4]. For details see PhoP Regulatory Domain and PhoP-PhoQ
  

For photosynthetic apparatus RR:

• PrrA in Rhodobacter sphaeroides
  

For WspR RR:

• WspR.

3D Structures of response regulator

Updated on 07-August-2016