Retinoblastoma-binding protein

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Contents 1 Function 2 Structural highlights 3 3D structures of retinoblastoma-binding protein 4 References

Function

Retinoblastoma-binding protein (RBBP) or histone-binding protein are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein^[1].

• RBBP1 regulates transcriptional activity^[2].
  
• RBBP2 demethylates histone H3 at lysine 4.
  
• RBBP5 is involved in methylation and dimethylation of histone H3.
  
• RBBP6 promotes p53 degradation^[3].
  
• RBBP7 is a WD-repeat protein that interacts with histone deacetylases^[4].
  
• RBBP9 blocks the binding of retinoblastoma protein to one of its signaling partners^[5].
  .

Structural highlights

RBBP7 interacts with histone H4 in a pocket between its N-terminal α helix and its negatively charged PP loop which contains 2 consecutive Pro residues^[6].
.

3D structures of retinoblastoma-binding protein

Updated on 07-August-2016

References

1. ↑ Woitach JT, Zhang M, Niu CH, Thorgeirsson SS. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 Aug;19(4):371-4. PMID:9697699 doi:http://dx.doi.org/10.1038/1258
2. ↑ Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al.. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov;8(11):3149-56. PMID:8414517
3. ↑ Motadi LR, Bhoola KD, Dlamini Z. Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology. 2011 Oct;216(10):1065-73. doi: 10.1016/j.imbio.2011.05.004. Epub, 2011 May 17. PMID:21676486 doi:http://dx.doi.org/10.1016/j.imbio.2011.05.004
4. ↑ Yang J, Kiefer S, Rauchman M. Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. Genomics. 2002 Oct;80(4):407-15. PMID:12376095
5. ↑ Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Pept Lett. 2012 Feb;19(2):194-7. PMID:21933118
6. ↑ Murzina NV, Pei XY, Zhang W, Sparkes M, Vicente-Garcia J, Pratap JV, McLaughlin SH, Ben-Shahar TR, Verreault A, Luisi BF, Laue ED. Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure. 2008 Jul;16(7):1077-85. Epub 2008 Jun 19. PMID:18571423 doi:http://dx.doi.org/10.1016/j.str.2008.05.006