Rho guanine nucleotide exchange factor

Function

Rho guanine nucleotide exchange factor (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein^[1]. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.

• Rho guanine nucleotide exchange factor 1 binds to G proteins and stimulate Rho-dependent signals.
  

Disease

Relevance

Structural highlights