1ni1
From Proteopedia
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| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Gene: | FNTA (Rattus norvegicus), FNTB (Rattus norvegicus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Imidazole and cyanophenyl farnesyl transferase inhibitors
Overview
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.
About this Structure
1NI1 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability., Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. PMID:12699757
Page seeded by OCA on Thu Mar 20 12:57:09 2008
Categories: Protein complex | Rattus norvegicus | Bauch, J. | Cohen, J. | Gu, W Z. | Hasvold, L. | Leonard, N. | Li, Q. | Li, T. | Lin, N H. | Marsh, K. | Rosenberg, S H. | Sham, H L. | Stoll, V. | Tong, Y. | Wang, L. | Wang, W. | Zhang, H. | 2C5 | HFP | ZN | Cyanophenyl | Ftase | Prenyltransferase | Transferase
