3w6g

Publication Abstract from PubMed

The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 A. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx).

Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii.,Nakamura T, Mori A, Niiyama M, Matsumura H, Tokuyama C, Morita J, Uegaki K, Inoue T Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):719-22. doi: , 10.1107/S1744309113014036. Epub 2013 Jun 27. PMID:23832195^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.